Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. Looking For More References? D2 mice, when young, have at least 3 times as many HSCs as B6. Natural variation in the size of endogenous stem cell populations is important for homeostatic tissue regeneration, stem cell transplantation, aging, and, potentially, organismal longevity.
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To ensure long-term funding for the OMIM project, we have diversified our revenue stream. We are determined to keep this website freely accessible. Lxn was less potent against other mammalian carboxypeptidases, m it did not inhibit other metallopeptidases or serine proteases.
D2 mice, when young, have at least 3 times as many HSCs as B6. See Using the Quick Search Tool for more information. Click on grid cells to view annotations.
The deduced amino acid protein is an elongated molecule with N- and C-terminal domains that each consist of an alpha helix enveloped by a curved beta sheet. Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid binding oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter.
They identified clusters of SNPs upstream of the Lxn transcriptional start site, at least 2 of which are associated with potential binding sites with transcription factors regulating stem cells.
Developmental Gene Expression In reciprocal chromosome 3 congenic mice, introgressed D2 alleles increased HSC numbers owing to enhanced proliferation and self-renewal and reduced apoptosis, whereas B6 alleles had the opposite effects. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin.
Mutations, Alleles, and Phenotypes. Northern blot analysis of several rat tissues and specific brain regions detected widespread expression of a single transcript, with highest levels in brain, lung, and digestive tract. Unfortunately, it is not free to produce.
LXN latexin [ (human)]
GXD’s primary emphasis is on endogenous gene expression during development. Expert curators review the literature and organize it to facilitate your work.
Using oligonucleotide arrays, real-time PCR, and protein blocks, Liang et al.
Expression was inversely correlated with the number of HSCs; ectopic expression of Lxn using a retroviral vector decreased stem cell population size. Use several keywords to find the most relevant results: Please join your colleagues by making a donation now and again in the future. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
Looking For M References? CPA4 is a compact protein hollowed out in a funnel-like shape, with the active site at the bottom of the funnel. Lxn interacts with 27 markers Mir26a-1Mir30bMira-1Donations are an important component of our efforts to ensure long-term funding to provide you the information that you need at your fingertips.
Tissue x Stage Matrix.
LXN latexin [ (human)]
A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. LXN, latexin Orthology source: Mice homozygous for a targeted null mutation display reduced sensitivity to acute thermal pain, which can be reversed by exogenous carboxypeptidase inhibitor. Latexin is a specific inhibitor of zinc-dependent metallocarboxypeptidases Pallares et al.
View this region in JBrowse. Search for genome features by name, symbol, synonym, homolog, allele, or accession ID: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine.
As reviewed by Liang et al.