Handbook of Reactive Chemical Hazards. Nature Genetics , Safety and health information systems: How to cite this article. Another possibility is the existence of a “modifier” gene that may act in concert with the MEN1 gene altering the predisposition to tumorigenesis. Melanoma Research , 9: Dangerous Properties of Industrial Materials.
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Recently, the MEN1 gene has been cloned from the 11q13 region and somatic mutations have been demonstrated in MEN1 patients, who are characterized by a predisposition to develop parathyroid, pituitary and pancreas tumors and also adrenal cortex and thyroid lesions 1,2, Sources of information in occupational health practice.
The Diseases of Occupations. Toxicological analytical facilities in Malaysia. Identification of the multiple endocrine neoplasia type 1 MEN1 gene. A major global vv problem. On the other hand, loss of function of tumor suppressor genes usually requires large deletions of chromosomal emmmert. We have studied parathyroid tumours not associated with MEN1 to determine whether somatic mutations in the MEN1 gene are present.
A ten years experience. On-line medical database searching. Mattos 2L. AU – Liotta, L. Among 33 tumours we found somatic MEN1 gene mutation in 7, while the corresponding MEN1 germline sequence was normal in each patient. American Journal of Pathology Certain statistics have not been updated since the production of the 4th edition of the Encyclopaedia Nature GeneticsVol.
All tumours with MEN1 gene mutation showed LOH on 11q13, making the tumour cells hemi- or homozygous for the mutant allele.
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AU – Collins, F. Positional cloning p the gene for multiple endocrine neoplasia-type 1. Human Molecular Genetics7: AU – Lubensky, I. PCR products were loaded from normal tissue from the contralateral lobe of a thyroid follicular carcinoma lane 1from the thyroid follicular carcinoma of the same patient loaded on lane 1 lane 2from a thyroid papillary carcinoma lane 3adrenocortical carcinoma lane 4adrenocortical carcinoma lane 5adrenal adenoma lane 6breast infiltrating ductal cancer lane 7and thyroid papillary carcinoma lane 8.
All samples were stored at o C until they were used.
Somatic mutation of the MEN1 gene in parathyroid tumours.
Another possibility is the existence of a “modifier” gene that may act in concert with the MEN1 gene altering the predisposition to tumorigenesis. Our results and those reported by others suggest that a tumor suppressor gene in 11q13 other than MEN1 might be involved in the development of these cancers.
PY – Y1 – N2 – Primary hyperparathyroidism is a common disorder emmetr an annual incidencce of approximately 0. Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Analysis of local, national and global methods. Am Ind Hyg Assoc J 5 Somatic mutation of the MEN1 gene in parathyroid tumours.
Lack of mutations of exon 2 of the MEN1 gene in endocrine and nonendocrine sporadic tumors
Tissue slices of lesions excised from the affected patients were reviewed by two of the authors P. In addition, LOH has been demonstrated in many non-MEN1-related tumors like breast cancer, where it has been suggested to harbor a tumor suppressor gene implicated in the transition from early preneoplastic lesions to invasive breast cancer We used 5 pairs of primers to encompass the complete coding sequence of exon 2 of the MEN1 gene that was screened by the polymerase chain reaction-single-stranded conformation polymorphism PCR-SSCP technique in 78 sporadic thyroid cancers: We examined exon 2 of this gene, where most of the mutations have been described, in endocrine and nonendocrine sporadic tumors.
In conclusion, by studying a large series of tumors, we demonstrated that exon 2 of the MEN1 gene is not involved in thyroid, adrenal or breast tumorigenesis. Cancer Research Accepted April 19,